Current Data Priorities for FB3
The following describes particular types of data that we have determined - through surveys and consultation with community expert scientists - will help enrich our data offerings to the community and fill in notable gaps. If you would like to submit such data for review, please see How to Submit Data to FaceBase 3.
Our plan is to re-assess these priorities with our Scientific Experts Panel annually during the FaceBase 3 funding period. We would also like to have feedback from the community. If you would like to contribute ideas to help shape these priorities, please use the FaceBase Feedback Form below.
Targeted model organisms:
We will continue to bolster our strengths in human, mouse, and zebrafish datasets.
Additionally, we will target expansion to chick and xenopus data.
Gaps in existing data:
- Systematic genomic analysis from well-defined, purified cell populations
- Facial GWAS and sequencing datasets from different populations, both normal-range and disease-associated variation
- Mouse histology, gene expression and 3D imaging of E8.5-E10.5
- Cell lines pertinent to orofacial tissues (e.g. neural crest)
- Detailed stage transcriptional and epigenetic analysis of zebrafish and mice
New data types
- Single-cell RNA sequencing (scRNAseq)
- Human and murine dental development
- Salivary gland and lacrimal gland, with a specific focus on developmental data
- Spatial transcriptomics data
- Curated resource list - A curated list of antibodies, recombinant proteins, and small molecules that have been authenticated by the research community specifically for their utility in craniofacial research would be a helpful community resource