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FaceBase Hub publication in JDR Special Issue | FaceBase

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FaceBase Hub publication in JDR Special Issue

Published 02 August 2022

The Hub is pleased to announce a new paper that was just published in a special issue of the Journal of Dental Research (Data-Driven Analytics for Dental, Oral, and Craniofacial Health Care) titled “FaceBase: A Community-Driven Hub for Data-Intensive Research”. This review article summarizes the last two and a half years of FaceBase’s community-driven, self-curation model and describes the resulting varied datasets published as a result. It also describes the importance of FAIR principles for data sharing.

Schuler RE, Bugacov A, Hacia JG, et al. FaceBase: A Community-Driven Hub for Data-Intensive Research. Journal of Dental Research. August 2022. doi:10.1177/00220345221107905


The FaceBase Consortium, funded by the National Institute of Dental and Craniofacial Research of the National Institutes of Health, was established in 2009 with the recognition that dental and craniofacial research are increasingly data-intensive disciplines. Data sharing is critical for the validation and reproducibility of results as well as to enable reuse of data. In service of these goals, data ought to be FAIR: Findable, Accessible, Interoperable, and Reusable. The FaceBase data repository and educational resources exemplify the FAIR principles and support a broad user community including researchers in craniofacial development, molecular genetics, and genomics. FaceBase demonstrates that a model in which researchers “self-curate” their data can be successful and scalable. We present the results of the first 2.5 y of FaceBase’s operations as an open community and summarize the data sets published during this period. We then describe a research highlight from work on the identification of regulatory networks and noncoding RNAs involved in cleft lip with/without cleft palate that both used and in turn contributed new findings to publicly available FaceBase resources. Collectively, FaceBase serves as a dynamic and continuously evolving resource to facilitate data-intensive research, enhance data reproducibility, and perform deep phenotyping across multiple species in dental and craniofacial research.

You can view all FaceBase publications here.