Data release: TGF-β Signaling and Craniofacial Morphogenesis
Published 20 May 2025
We are excited to announce new data releases from a Nature Communications paper on TGF-β Signaling and Craniofacial Morphogenesis featuring high resolution spatial genomics data!
High-resolution spatial transcriptomics and cell lineage analysis reveal spatiotemporal cell fate determination during craniofacial development (2 datasets) Principal Investigator: Yang Chai (University of Southern California)
Citation:
Feng, Jifan & Janeckova, Eva & Guo, Tingwei & Ziaei, Heliya & Zhang, Mingyi & Geng, Jessica & Cha, Sa & Araujo-Villalba, Angelita & Liu, Mengmeng & Ho, Thach-Vu & Chai, Yang. (2025). High-resolution spatial transcriptomics and cell lineage analysis reveal spatiotemporal cell fate determination during craniofacial development. Nature Communications. 16. 10.1038/s41467-025-59206-2.
The authors employed scRNA-seq analysis alongside a seqFISH-based spatial genomics approach for high-resolution visualization of spatially resolved gene expression profiles for the developing palate and other craniofacial regions in the mouse embryos. The raw and processed scRNA-seq data from embryonic palatal tissue at different developmental stages (E12.5, E13.5, E14.5, E15.5, and E18.5) generated in this study has been deposited in FaceBase under the DOI 10.25550/62-QZ1A. The raw and processed sequencing-FISH data for anterior and posterior embryonic heads at E12.5, E13.5, and E15.5 are available in the FaceBase database under the DOI 10.25550/62-Y0VT.
