FaceBase - Comprehensive data and resources for craniofacial researchers
FaceBase is a collaborative NIDCR-funded consortium generating data in support of advancing research into craniofacial development and malformation. Members of the consortium contribute large datasets of a variety of types and make them available to the wider research community via this website. Read the FAQs.
Featured Publications View all FaceBase publications here.
Fine tuning of craniofacial morphology by distant-acting enhancers.
Attanasio C, Nord AS, Zhu Y, Blow MJ, Li Z, Liberton DK, Morrison H, Plajzer-Frick I, Holt A, Hosseini R, Phouanenavong S, Akiyama JA, Shoukry M, Afzal V, Rubin EM, FitzPatrick DR, Ren B, Hallgrímsson B, Pennacchio LA, Visel A. Science. 2013 Oct 25;342(6157):1241006. doi: 10.1126/science.1241006.
Integration of comprehensive 3D microCT and signaling analysis reveals differential regulatory mechanisms of craniofacial bone development.
Ho TV, Iwata J, Ho HA, Grimes WC, Park S, Sanchez-Lara PA, Chai Y. Dev Biol. 2015 Apr 15;400(2):180-90. doi: 10.1016/j.ydbio.2015.02.010. Epub 2015 Feb 23.
Enhancer Divergence and cis-Regulatory Evolution in the Human and Chimp Neural Crest
Prescott SL, Srinivasan R, Marchetto MC, Grishina I, Narvaiza I, Selleri L, Gage FH, Swigut T, Wysocka J. Cell. 2015 Sep 24;163(1):68-83. doi: 10.1016/j.cell.2015.08.036. Epub 2015 Sep 10.
The Old And New Face Of Craniofacial Research: How Animal Models Inform Human Craniofacial Genetic And Clinical Data. (Review)
Van Otterloo E, Williams T, Artinger KB. Dev Biol. 2016 Jan 22. pii: S0012-1606(16)30030-6. doi: 10.1016/j.ydbio.2016.01.017. [Epub ahead of print]
Molecular Anatomy of Palate Development
Potter AS, Potter SS. PLoS One. 2015 Jul 13;10(7):e0132662. doi: 10.1371/journal.pone.0132662. eCollection 2015.
The ontology of craniofacial development and malformation for translational craniofacial research.
Brinkley JF, Borromeo C, Clarkson M, Cox TC, Cunningham MJ, Detwiler LT, Heike CL, Hochheiser H, Mejino JL, Travillian RS, Shapiro LG. Am J Med Genet C Semin Med Genet. 2013 Nov;163C(4):232-45. doi: 10.1002/ajmg.c.31377. Epub 2013 Oct 4.
Browse the Data Repository by Attributes Get started with one of these or start from scratch.
Try the new Mouse Matrix to visualize our mouse data.
Anatomical Resources
Mouse Anatomy and Age Stage Matrix
Datasets by mouse anatomy and age stages.
Mouse Anatomy
Images of mouse anatomical features by age stage.
FishFace
Developmental atlas of zebrafish.
OCDM
Ontology for craniofacial anatomy and development.
Genetic Repositories and Resources
Gene Summary
Descriptions of selected genes for mouse and human. Includes gene expression pattern drawings and links to related FaceBase datasets.
Genome Browser
Our custom track on the UCSC Genome Browser.
Gene Expression Omnibus
Curated set of mouse gene expression data.
Human Genomics Analysis Interface
Open access to genomics data.
3D Imaging Resources
3D Facial Norms Database
High-quality craniofacial anthropometric normative data.
CranioGUI
Software to analyze facial abnormalities.
Using 3D Viewers in the Data Browser
Information on viewing 3D imaging data.
- Click here or in the menu click Data then Data Browser. Then choose from attributes in the sidebar to show results by organism, experiment type, data type, and many others.
- In the Search within attributes... box at the top of the sidebar, you can type in a keyword and see which attributes include that keyword.
- Read Using the Data Browser for more information.
FaceBase Data fits into one of two broad categories: open and restricted access.
Open access is available on the FaceBase website to any interested user and does not require any formal registration. Open-access data is limited to summary-level human data (ex: averaged facial measures), and all non-human data.
Restricted access includes all individual-level human data (ex: demographic descriptors, phenotypic measures, 3D images) and requires the requestor to complete and submit the Data Access Request form as described in How do I request access to restricted human data?
- Complete the FaceBase Data Use Certification Agreement.
- Complete the Data Access Request (DAR) document, and an IRB approval from your institution.
- Submit the Data Use Certification Agreement, DAR, and the IRB approval to the NIH Data Access Committee at dac AT facebase.org
You shall receive an answer from the Data Access Committee within 4-6 weeks - Once your request is processed, you are notified via email that your user account is approved for human dataset downloads. Note that this permission to download human data expires 180 days after the date of approval.
If you have any questions regarding this process or need help with downloads please contact the FaceBase Help Desk via email: help AT facebase.org.
Due to constraints as we're developing the new data model, we are not accepting outside contributions at this time.
News
- 05/18/2016 - Presentations from the 2016 FaceBase Annual Meeting in Denver
- 03/02/2016 - 2016 FaceBase Annual Meeting in Denver May 2-3
- 02/09/2016 - Upgrade to FaceBase authentication - Phase 1 on Feb 13th
- 12/14/2015 - Site updates - First new FB2 datasets now available
- 10/13/2015 - Site updates - Homepage Links and Data Browser UI
