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Comprehensive craniofacial data and resources
Your curated, one-stop shop for facial development and research.

Explore our repository:

Search over 1,000 datasets by organisms, experiment type, age stage, mutation, genotype and more.

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Watch this introductory video: (4 mins 38 secs)

2022 FaceBase Poster Competition Finalists
Here are the top posters from the 2022 FaceBase Community Forum.

First place score was a three-way tie:

  • Alleviation of Ciliopathic Craniofacial Anomalies by Disrupting Sufu-Gli Interaction Ching-Fang Chang (Cincinnati Children's Hospital)
  • Spatiotemporal Single-cell Atlas Reveals Cell Lineage Diversification During Tooth Morphogenesis Junjun Jing (USC)
  • Deconstructing Calcineurin/NFAT Signaling in Species with Distinct Midfacial Outgrowth Tiange Qu (UCSF)

Second place score was a two-way tie:

  • Midface Epithelium scRNAseq Reveals Spatiotemporal Dynamics in Cleft Lip/Palate Model Brandon Chacon (UCSF)
  • Tissue-specific Roles of ESCRT Machinery Component VPS25 in Craniofacial Morphogenesis Viviana Hermosilla Aguayo (UCSF)

Third place score was a three-way tie:

  • Shared Genetic Risk Between Cleft Subtypes in the African Population Azeez Alade (Iowa Institute for Oral Health Research)
  • TGF-β Signaling Regulates Pharyngeal Muscle Development via Mediating Cell-cell Interaction Jifan Feng (USC)
  • Arid1b is Indispensable in Regulating Mesenchymal Stem Cell Homeostasis Mingyi Zhang (USC)

Publications Spotlight
View all FaceBase publications here.

  1. FaceBase: A Community-Driven Hub for Data-Intensive Research

    Schuler, R.E.; Bugacov, A.; Hacia, J.G.; Ho, T.V.; Iwata, J.; Pearlman, L.; Samuels, B.D.; Williams, C.; Zhao, Z.; Kesselman, C.; Chai, Y.. Journal of Dental Research. , 002203452211079. July 2022.

    The FaceBase Consortium, funded by the National Institute of Dental and Craniofacial Research of the National Institutes of Health, was established in 2009 with the recognition that dental and craniofacial research are increasingly data-intensive disciplines. Data sharing is critical for the validation and reproducibility of results as well as to enable reuse of data. In service of these goals, data ought to be FAIR: Findable, Accessible, Interoperable, and Reusable. The FaceBase data repository and educational resources exemplify the FAIR principles and support a broad user community including researchers in craniofacial development, molecular genetics, and genomics. FaceBase demonstrates that a model in which researchers “self-curate” their data can be successful and scalable. We present the results of the first 2.5 y of FaceBase’s operations as an open community and summarize the data sets published during this period. We then describe a research highlight from work on the identification of regulatory networks and noncoding RNAs involved in cleft lip with/without cleft palate that both used and in turn contributed new findings to publicly available FaceBase resources. Collectively, FaceBase serves as a dynamic and continuously evolving resource to facilitate data-intensive research, enhance data reproducibility, and perform deep phenotyping across multiple species in dental and craniofacial research.

  2. Marsupials and Multi-Omics: Establishing New Comparative Models of Neural Crest Patterning and Craniofacial Development

    Newton, Axel H.. Frontiers in Cell and Developmental Biology. vol. 10, 941168. June 2022.

    Studies across vertebrates have revealed significant insights into the processes that drive craniofacial morphogenesis, yet we still know little about how distinct facial morphologies are patterned during development. Studies largely point to evolution in GRNs of cranial progenitor cell types such as neural crest cells, as the major driver underlying adaptive cranial shapes. However, this hypothesis requires further validation, particularly within suitable models amenable to manipulation. By utilizing comparative models between related species, we can begin to disentangle complex developmental systems and identify the origin of species-specific patterning. Mammals present excellent evolutionary examples to scrutinize how these differences arise, as sister clades of eutherians and marsupials possess suitable divergence times, conserved cranial anatomies, modular evolutionary patterns, and distinct developmental heterochrony in their NCC behaviours and craniofacial patterning. In this review, I lend perspectives into the current state of mammalian craniofacial biology and discuss the importance of establishing a new marsupial model, the fat-tailed dunnart, for comparative research. Through detailed comparisons with the mouse, we can begin to decipher mammalian conserved, and species-specific processes and their contribution to craniofacial patterning and shape disparity. Recent advances in single-cell multi-omics allow high-resolution investigations into the cellular and molecular basis of key developmental processes. As such, I discuss how comparative evolutionary application of these tools can provide detailed insights into complex cellular behaviours and expression dynamics underlying adaptive craniofacial evolution. Though in its infancy, the field of “comparative evo-devo-omics” presents unparalleled opportunities to precisely uncover how phenotypic differences arise during development.