Welcome to the EnamelBase!
Defects in tooth enamel are associated with a multitude of health conditions. Although significant progress has been made in our understanding of enamel formation, many crucial questions remain unanswered. The purpose of this community resource is to provide a toolkit of sophisticated genetic mouse reagents that are physiologically relevant, robust, and validated. These reagents will are accompanied by stage-specific and even single cell level information on [gene expression] and translation, and complemented by an in-depth characterization of the structure, composition, and mechanical properties of forming and mature enamel at overlapping length scales. By mapping gene expression, specifying local proteomes, and quantitatively assessing impact of the perturbations at each of these levels on the materials properties of enamel, we hope that this platform will empower enamel researchers, help delineate mechanisms of disease, and enable the development of new approaches of intervention.
The Diekwisch Laboratory at the University of Rochester Medical Center School of Medicine and Dentistry (URMC)
The Hu Laboratory at the University of Michigan, Ann Arbor
The Joester Laboratory at Northwestern University (NU)
The Klein Laboratory at the University of California, San Francisco (UCSF)
The Paine Laboratory at the University of Southern California (USC)
We encourage contributions to the EnamelBase by other groups working on amelogenesis. Please review the process and complete the submission form as described here.
Data in this repository was generated with support from the National Institute of Health, the National Institute of Dental and Craniofacial Research (NIH-NIDCR), through the following Exploratory/Developmental Phased Award Cooperative Agreements under the Funding Opportunity “Encouraging Development of Novel Amelogenesis Models”, Funding Announcement Number RFA-DE-19-004 :
- UG3/UH3 DE028869 “Ameloblast Differentiation and Amelogenesis: Next-Generation Models to Define Key Mechanisms and Factors Involved in Biological Enamel Formation”.
- UG3/UH3 DE028850 “Cre Mouse Models to Study amelogenesis”.
- UG3/UH3 DE028849 “Development and Validation of Novel Amelogenesis Models”.
- UG3/UH3 DE028872 “Enamel Atlas: Systems-level Amelogenesis Tools at Multiple Scales”.