EnamelBase: Mouse Models

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Projects and Data Links Amelogenesis: A Primer Mouse Models Protocols

The following table describes a suite of innovative mouse models, including amelogenesis-stage specific constitutive and inducible Cre drivers, reporters, conditional knock-out, and targeted mutant models. These models target structural and proteolytic proteins of the enamel matrix, trans-membrane ion transporters, and intracellular proteins associated with vesicular transport.

Mutant Allele	Group	Mouse Chromosome (ENSEMBLE)	Map and genotyping protocol			MMRRC Depository ID	Verification Method	Deposited By
MMP20 flox	LoxP insertion	Ch. 9	MAP WT	MAP MUTANT	Genotyping Protocol	68130	LoxP Recombination	Klein Lab
KLK4 flox	LoxP insertion	Ch. 7	MAP WT	MAP MUTANT	Genotyping Protocol	68131	LoxP Recombination	Klein Lab
AMTN flox	LoxP insertion	Ch. 5	MAP WT	MAP MUTANT	Genotyping Protocol	68132	LoxP Recombination	Klein Lab
AMELX flox	LoxP insertion	Ch. X	MAP WT	MAP MUTANT	Genotyping Protocol	68129	LoxP Recombination	Klein Lab
ENAM flox	LoxP insertion	Ch. 5	MAP WT	MAP MUTANT	Genotyping Protocol	in progress	LoxP Recombination	Klein Lab
AMBN flox	LoxP insertion	Ch. 5	MAP WT	MAP MUTANT	Genotyping Protocol	in progress	LoxP Recombination	Klein Lab
ODAM flox	LoxP insertion	Ch. 5	MAP WT	MAP MUTANT	Genotyping Protocol	Submitted, waiting for approval	n/a	Klein Lab
CLTC Flox	LoxP insertion	Ch. 11	MAP WT	MAP MUTANT	Genotyping Protocol	68093	LoxP Recombination	Diekwisch Lab
AMELX-E3-GGG	Targeted mutation	Ch. X	MAP WT	MAP MUTANT	Genotyping Protocol	68127	Locus sequencing	Klein Lab
AMELX-E5-GGG	Targeted mutation	Ch. X	MAP WT	MAP MUTANT	Genotyping Protocol	68128	Locus sequencing	Klein Lab
AMBN-A254_Y255insX	Targeted mutation	Ch. 5	MAP WT	MAP MUTANT	Genotyping Protocol	in progress	Locus sequencing	Klein Lab
XYZ-CreERT2	Knock out/Knock-in	TBA	MAP WT	MAP MUTANT	Genotyping Protocol	n/a	n/a	Klein Lab
Proser2-EYFP	Knock out/Knock-in	Ch. 2	MAP WT	MAP MUTANT	Genotyping Protocol	n/a	n/a	Klein Lab
AMBN-Cre	Knock out/Knock-in	Ch. 5	MAP WT	MAP MUTANT	Genotyping Protocol	68135	TdTomato expression	Klein Lab
AMBN-IRESCre	IRES	Ch. 5	MAP WT	MAP MUTANT	Genotyping Protocol	67446	LacZ expression	Paine Lab
AMBN-CreERT2	Knock out/Knock-in	Ch. 5	MAP WT	MAP MUTANT	Genotyping Protocol	Submitted, waiting approval	TdTomato expression	Klein Lab
AMBN-p2A-EGFP	p2A	Ch. 5	MAP WT	MAP MUTANT	Genotyping Protocol	68134	GFP expr. in secretory ameloblasts	Klein Lab
AMELX-p2A-Cre	p2A	Ch. X	MAP WT	MAP MUTANT	Genotyping Protocol	68136	TdTomato expression	Klein Lab
AMELX-p2A-CreERT2	p2A	Ch. X	MAP WT	MAP MUTANT	Genotyping Protocol	Submitted, waiting for approval	n/a	Klein Lab
Slc13a5R337X	Targeted mutation	Ch. 11	MAP WT	MAP MUTANT	Genotyping Protocol	67433	Sanger sequencing	Hu Lab
Slc13a519del	Spontaneous Deletion	Ch. 11	MAP WT	MAP MUTANT	Genotyping Protocol	67434	Sanger sequencing	Hu Lab
Slc13a5Flag	Targeted insertion	Ch. 11	MAP WT	MAP MUTANT	Genotyping Protocol	68041	Sanger sequencing, Flag expression by IHC	Hu Lab
OdaphC41X	Targeted mutation	Ch. 5	MAP WT	MAP MUTANT	Genotyping Protocol	67431	Sanger sequencing	Hu Lab
OdaphIns	Spontaneous Insertion	Ch. 5	MAP WT	MAP MUTANT	Genotyping Protocol	67432	Sanger sequencing	Hu Lab
KLK4-Cre	Knock out/Knock-in	Ch. 7	MAP WT	MAP MUTANT	Genotyping Protocol	68133	TdTomato expression	Klein Lab
KLK4-CreERT2	Knock out/Knock-in	Ch. 7	MAP WT	MAP MUTANT	Genotyping Protocol	Submitted, waiting for approval	TdTomato expression	Klein Lab
KLK4-p2A-mCherry	p2A	Ch. 7	MAP WT	MAP MUTANT	Genotyping Protocol	Submitted, waiting for approval	mCherry in maturation stage ameloblasts	Klein Lab
ODAM-IRESCre	IRES	Ch. 5	MAP WT	MAP MUTANT	Genotyping Protocol	67402	LacZ expression	Paine Lab