Page 6 of 18 for News & Events

Introducing the EnamelBase resource (13 March 2023)

FaceBase is excited to introduce EnamelBase hosted by FaceBase, a sharing site for data, tools, and resources to accelerate scientific and technical progress in studying a multi-stage process of dental enamel formation called amelogenesis.

Tools and resources are available now and coming soon at https://www.facebase.org/resources/enamelbase/, including:

Mouse Models: 20+ mutant, conditional-ready, Cre-driver, and reporter models available at MMRRC.
In vitro bioreactor: A 3D co-culture system for the expansion and maintenance of ameloblast-like cells
Protocols: To support secondary use of models and generation of enamel-focused datasets
Multiple Data Types: Morphological, biochemical, histological, biophysical, high-resolution structural images, and multi-scale omics data

Save the date for the 3rd Annual FaceBase Community Forum on Tuesday, June 13th! (14 February 2023)

Join the craniofacial research community for a day of in-person and virtual knowledge sharing at the 3nd Annual FaceBase Community Forum!

FaceBase will be hosting this year’s Forum at the at the Health Sciences Campus at University of Southern California on Tuesday, June 13th.

Check this event page, your inbox (if you’re a subscriber or member), and our Twitter account for more details as they’re confirmed!

New video available describing images and imaging resources in FaceBase (13 September 2022)

FaceBase is happy to release a new video that walks you through the rich variety of imaging data and imaging resources available in FaceBase for the craniofacial research community.

View the video below (running time 5:55):

Here is a list of specific resources referenced in the video:

Histological Image Viewer

Dataset “Activity of human neural crest enhancer near GPR158 in E11.5 transgenic mouse embryo – Tg(hg38_chr10:25522061-25522992::LacZ).”: https://www.facebase.org/id/1-3SF2
Annotations Editor example from Dataset “Histology and schematic overview of mouse molar root development”: https://www.facebase.org/id/1-W96W

Volumetric Image Viewer

Dataset “microCT - Soft Tissue of C57BL6 mouse at E15.5”: https://www.facebase.org/id/TJR

Surface Mesh Viewer

Dataset “E18.5 wildtype mouse microCT”: https://www.facebase.org/id/3V4A

Curated Imaging Resources

FaceBase publication in JDR Special Issue (02 August 2022)

FaceBase is pleased to announce a new paper that was just published in a special issue of the Journal of Dental Research (Data-Driven Analytics for Dental, Oral, and Craniofacial Health Care) titled “FaceBase: A Community-Driven Hub for Data-Intensive Research”. This review article summarizes the last two and a half years of FaceBase’s community-driven, self-curation model and describes the resulting varied datasets published as a result. It also describes the importance of FAIR principles for data sharing.

Schuler RE, Bugacov A, Hacia JG, et al. FaceBase: A Community-Driven Hub for Data-Intensive Research. Journal of Dental Research. August 2022. doi:10.1177/00220345221107905

Abstract:

The FaceBase Consortium, funded by the National Institute of Dental and Craniofacial Research of the National Institutes of Health, was established in 2009 with the recognition that dental and craniofacial research are increasingly data-intensive disciplines. Data sharing is critical for the validation and reproducibility of results as well as to enable reuse of data. In service of these goals, data ought to be FAIR: Findable, Accessible, Interoperable, and Reusable. The FaceBase data repository and educational resources exemplify the FAIR principles and support a broad user community including researchers in craniofacial development, molecular genetics, and genomics. FaceBase demonstrates that a model in which researchers “self-curate” their data can be successful and scalable. We present the results of the first 2.5 y of FaceBase’s operations as an open community and summarize the data sets published during this period. We then describe a research highlight from work on the identification of regulatory networks and noncoding RNAs involved in cleft lip with/without cleft palate that both used and in turn contributed new findings to publicly available FaceBase resources. Collectively, FaceBase serves as a dynamic and continuously evolving resource to facilitate data-intensive research, enhance data reproducibility, and perform deep phenotyping across multiple species in dental and craniofacial research.

You can view all FaceBase publications here.

Winners of the 2022 FaceBase Poster Competition! (21 June 2022)

We had an amazing time at the 2022 FaceBase Community Forum last week with great talks and interactions. Needless to say, it was also a joy to be able to see colleagues in person for the first time in years! We’ll be posting some materials available for the public soon.

But first, we wanted to celebrate our poster finalists! The posters with the top scores were:

First Place (Tie)

Ching-Fang Chang (Cincinnati Children’s Hospital), “Alleviation of Ciliopathic Craniofacial Anomalies by Disrupting Sufu-Gli Interaction”
Junjun Jing (USC), “Spatiotemporal Single-cell Atlas Reveals Cell Lineage Diversification During Tooth Morphogenesis”
Tiange Qu (UCSF), “Deconstructing Calcineurin/NFAT Signaling in Species with Distinct Midfacial Outgrowth “

Second Place (Tie)

Brandon Chacon (UCSF), “Midface Epithelium scRNAseq Reveals Spatiotemporal Dynamics in Cleft Lip/Palate Model”
Viviana Hermosilla Aguayo (UCSF), “Tissue-specific Roles of ESCRT Machinery Component VPS25 in Craniofacial Morphogenesis”

Third Place (Tie)

Azeez Alade (Iowa Institute for Oral Health Research), “Shared Genetic Risk Between Cleft Subtypes in the African Population”
Jifan Feng (USC), “TGF-β Signaling Regulates Pharyngeal Muscle Development via Mediating Cell-cell Interaction”
Mingyi Zhang (USC), “Arid1b is Indispensable in Regulating Mesenchymal Stem Cell Homeostasis”

Congratulations to our winners and all of the poster presenters at this year’s Community Forum!